tutto attaccato o staccato

This experience promises new age interpretation of Carnatic Classical Krithis, seamless amalgamation of nostalgic film music with a contemporary twist and mellifluous originals composed for social causes that has been well received by the band’s fans and followers. Staccato is a Chennai based band, popularizing the genre Contemporary Classic, keen on giving an experiential listening to its audience. Staccato performs for Music Festivals, Concerts, Corporate Gigs, Cultural events, and Social events. If the compound is delivered orally, the compound’s bioavailability and metabolism will determine the Staccato OBT dose. Unlike many other inhalation technologies, the patient does not need to coordinate inhalation with other actions, and the patient does not need to learn a special breathing pattern. The patient inhales optimally sized particles of pure drug down into the narrower, more vascularized tissue of the deep lung, allowing fast and more complete absorption into the bloodstream for rapid systemic effect. To use Staccato OBT, a patient simply places the device to their lips and inhales (there is no waiting or prep time). Význam slova staccato ve slovníku cizích slov včetně překladů do angličtiny, francouzÅ¡tiny a ruÅ¡tiny. Obvykle tón netrvá po celou zapsanou délku noty, ale je zkrácen a zbytek trvání noty nahrazen pauzou. or. Význam: krátce, oddělovaně, odráženě . The drug is vaporized off the substrate within 500 milliseconds and drawn into the patient’s lungs within 1 second for absorption into systemic circulation. See more. Corporate Headquarters → staccare, staccarsi 2a. Det Danske Sprog- og Litteraturselskab 2018. Sections of this page. Jump to. Two Phase 1 clinical studies with our migraine and breakthrough pain programs have directly compared delivery of the same dose by IV and Staccato OBT. Thus, if there is an existing IV formulation for the compound of choice, then that is the most appropriate dose for the Staccato OBT. The Staccato device is breath actuated. The Staccato OBT products are reviewed as drug products by the FDA’s Center for Drug Evaluation and Research division. Sign Up. The Staccato OBT devices can incorporate multiple features, including lockout to enhance safety, the convenience of patient titration, and a variety of dose administration regimens. Alimentatore Xbox 360 staccato o attaccato? Clinical studies with a number of Staccato OBT product candidates have demonstrated patient compliance and confirmed that the intuitive nature of inhaling in a single breath to receive the dose is suitable for patients with acute conditions. Facebook. Translation Spell check Synonyms Conjugation. Speed of therapeutic onset is comparable (almost identical) to IV administration, generally achieving peak plasma levels of drug in 2 to 5 minutes. After vaporization, the drug cools rapidly in air, condensing into pure drug aerosol particles of near ambient temperature. Staccato definition, shortened and detached when played or sung: staccato notes. Compounds with low bioavailability and high first-pass hepatic metabolism will most likely have a significantly reduced dose in a Staccato OBT. STACCATO Flats Series. Filter by Product categories To find out if your compound will work in the Staccato OBT system, please contact our Business Development Group. Han var en mand, der levede i staccato, som talte, løb ind og ud af døre og aldrig blev siddende i en stol mere end et kvarter Pol1987 Politiken (avis), 1987. favi ma perchè tutto attaccato si scrive staccato e staccato si scrive tutto attaccato? Rapid peak plasma levels with a simple breath. Infatti non dici mai ho "tutto attaccato" la spina della corrente, bensì ho attaccato la spina. Staccato je styl hudebního přednesu, kdy jsou jednotlivé tóny hrány s co nejvýraznějÅ¡ím oddělením. At this first time point measured, patients with underlying schizophrenia and bipolar disorder taking Staccato loxapine showed significant improvement in their agitation symptoms versus placebo. A single inhalation actuates the Staccato OBT device and delivers the drug. Un conto è infatti il trattamento dell’interiezione (il saluto, in buona sostanza), un altro conto è il trattamento grafico del sostantivo. L' alimentatore va staccato o attaccato?? Výslovnost: stakato. Because the duration of drug heating is so brief, thermal decomposition is minimal. STACCATO Season Lookbook. Press alt + / to open this menu. :(Answer Save. Accessibility Help. Rapid vaporization of a pure drug film (rather than mechanically generating aerosols or utilizing preformed particles) enables consistent generation of particles averaging 1–5 microns in size, optimal for deep lung inhalation. Moeser. Staccato’s Clients include Saint Gobain, TNPL, Madras Cricket Club, TVS, Sanmar, Standard Charted Bank ,The Hindu, Young Indians, etc. The dose cartridge contains a single dose of a drug in milligram quantities, Each metal substrate rapidly heats upon application of battery-supplied electric current, Thin film of unformulated drug coated on the substrate, Breath activation—senses inhalation to automatically trigger aerosol generation, Dosing lockout features to prevent overdose and to manage patient titration, Wireless (Bluetooth) communication for patient monitoring and dose tracking. Italsko-český slovník zdarma. good morning - Traduzione del vocabolo e dei suoi composti, e discussioni del forum. Titular character Johnny Staccato, played by John Cassavetes, is a jazz pianist/private detective. Our commercial product ADASUVE (loxapine) inhalation powder (ADASUVE.com) and drug product candidates in our pipeline have demonstrated statistically significant onset of therapeutic effect within 10 minutes. Onset of action is more rapid compared to other drug delivery methods such as oral tablets, fast-dissolve tablets, sublingual films, and intramuscular and subcutaneous injections. Rapportér et problemfra Den Danske Ordbog Den Danske Ordbog. [5] (The King's Theatre, the second on this site, eventually became Her Majesty's Theatre, where Phantom of the Opera has enjoyed a long run in London. The vaporized drug cools and condenses into pure drug aerosol particles. staccato definition: 1. used to describe musical notes that are short and separate when played, or this way of playing…. Co znamená staccato? TEL: 650 944 7000 Obvykle tón netrvá po celou zapsanou délku noty, ale je zkrácen a zbytek trvání noty nahrazen pauzou.. Staccato se v notovém zápisu označuje tečkou nad nebo pod notou. All Staccato OBT devices are designed to actuate with minimal inhalation effort. Have performed in London , Rio De janerio , Muscat, Malaysia , Bali and all over India. … In less than half a second, the drug is heated to a temperature sufficient to convert the solid drug film into a vapor. A két ellentét között megkülönböztetnek egy köztes esetet is, melyet a szaknyelv mezzo staccatónak nevez.. A vonósok számára előírt staccato vonóval adandó elő, azaz nem a pizzicato egyik válfaja. See more of Favij on Facebook. In less than half a second, the drug is heated to a temperature sufficient to convert the solid drug film into a vapor. The Staccato OBT system delivers a consistent dose across a wide range of inhalation styles. After vaporization, the drug cools rapidly in air, condensing into pure drug aerosol particles of near ambient temperature. A single inhalation actuates the Staccato OBT system and delivers the drug. Email or Phone: Password: Forgot account? dipende dal significato: se è per dire "qualche volta" allora si scrive "a volte". The Staccato OBT system generates optimally sized aerosolized drug particles with consistent particle size distribution. In the pivotal studies with ADASUVE® (loxapine) inhalation powder (Staccato loxapine), statistically significant onset of effect was observed as early as 10 minutes after dosing. 1. p.pass. FAX: 650 944 7999 These aerosol particles are rapidly absorbed, resulting in peak plasma blood levels obtained in the first few minutes after administration. Io solitamente lascio la spina attaccata ma stacco l'altra estremità del cavo dall' alimentatore mentre il 2° cavo (quello che attacca alimentatore a Xbox) lo lascio attaccato. When the patient draws a breath through the Staccato OBT system, the substrate surface instantaneously heats to create a condensation aerosol. Update: Ovviamente intendo a Console spenta!! Filter by Product categories For dose delivery by the Staccato OBT system, no priming, hand/breath coordination, or forceful inhalation is required—the aerosol is simply entrained in the patient’s breath. A dire il vero "staccato" è il contrario di "attaccato", e non di "tutto attaccato". avvolte (tutto attaccato) se ti riferisci al verbo "avvolgere",altrimenti se vuoi dire qualche volta è(staccato) 1 1. melissabasilici. A variety of functional groups may be acceptable depending on their particular molecular arrangement as well as other physical and chemical properties of the drug. There is no general rule. The unique feature of the Staccato OBT is achievement of a consistently delivered fine particle dose regardless of the patient's breathing pattern. The profiles indicated that the Staccato OBT generates PK profiles very similar (almost identical) to IV, with the same bioavailability and peak plasma levels. A large number of molecules have demonstrated technical feasibility with Staccato technology. Veramente non riesco a capirlo!!! Buonanotte o buona notte: si scrive attaccato o staccato, qual è la regola dell'Accademia della Crusca e i dubbi su buongiorno. Learn more. Performed for the Hindu November Fest 2018 at Chennai, Bengaluru & Hyderabad. Reverso for Windows. The heart of the hand-held Staccato OBT system is a heated stainless steel substrate, onto which a thin film of unformulated drug is coated. Create New Account. způsob hry angličtina: staccato francouzÅ¡tina: staccato m němčina: Staccato s Pick a style below, and copy the text for your bibliography. The Staccato OBT system generates optimally sized aerosolized drug particles with consistent particle size distribution. Immediate absorption of the drug results in rapid onset of action and therapeutic effect. Conjugation Documents Grammar Dictionary Expressio. A screening feasibility study can be performed to determine a molecule's feasibility for thermal vaporization. Log In. Rapid vaporization of a pure drug film (rather than mechanically generating aerosols or utilizing preformed particles) enables consistent generation of particles averaging 1–5 microns in size, optimal for deep lung inhalation. The aerosol produced with the Staccato OBT system is designed to be absorbed rapidly through the deep lung. Staccato OBT products generate a pharmacokinetic profile similar (almost identical) to IV delivery while delivering medicine in a non-invasive way. Filter by Custom Post Type. Represented India at the World Freestyle Percussion event ‘Tum Tum Pa’ conducted by Redbull at Rio De Janerio, Brazil. In addition to delivering aerosol from a single active compound, the Staccato technology can also be used for delivery of a combination of different actives in a single breath. 1 decade ago. Filter by Custom Post Type. The Staccato OBT system can be customized to enhance safety and security to accommodate a variety of dose administration regimens including: Staccato OBT products are designed with patients’ use in mind. CIVIUM. perchè una è una parola e l altra son 2, se scrivi "tutto staccato" vedi che son 2 Bisogna distinguere a seconda della categoria grammaticale. staccato meaning: 1. used to describe musical notes that are short and separate when played, or this way of playing…. . The development team at Alexza designed the Staccato OBT devices with the patient in mind. Dose delivery by Staccato OBT does not require priming, hand/breath coordination, or forceful inhalation—the aerosol is simply generated and entrained in the patient's breath. 2091 Stierlin Court Mountain View, CA 94043 Il vero contrario di "tutto attaccato" è "tutto staccato", quindi la tua domanda è … Synopsis. The Staccato OBT devices meet the need of different therapeutic treatments. Perché "tutto attaccato" si scrive staccato, mentre "staccato" si scrive tutto attaccato? It is known as Perché tutto attaccato si scrive staccato mentre staccato si scrive tutto attaccato? Alexza has demonstrated that for the products tested to date, peak plasma levels have been achieved within 2 to 5 minutes of inhalation. :) Answer Save. More. The Alexza clinical team has conducted a number of clinical studies with Staccato OBT products where speed of onset has been evaluated. If the drug compound has already been approved in a formulation such as oral or IV, a 505(b)(2) regulatory strategy may be considered for a Staccato OBT product. Therefore, that information is unavailable for most Encyclopedia.com content. Driven by zeal and passion to explore and learn new forms of music and incorporating our cultural roots make Staccato a very unique band from Chennai. Rapid heating ensures minimal thermal decomposition. Moreover, molecular weight is usually key, in that macromolecules, peptides, and proteins generally do not work in our technology. Se è il participio passato del verbo "avvolgere" allora si scrive attaccato… to p.pass., agg., s.m. It has been described by theorists and has appeared in music since at least 1676. The Staccato OBT system can deliver both water-soluble and water-insoluble compounds without the need for excipients and additives such as detergents, stabilizers, and solvents, enabling the delivery of unformulated drug. Compounds from many different therapeutic areas have shown initial vaporization feasibility. Staccato ([stakˈkaːto]; Italian for "detached") is a form of musical articulation.In modern notation, it signifies a note of shortened duration, separated from the note that may follow by silence. Email Us, Approved (FDA and EMA) drug delivery system, Demonstrated efficient clinical development, Proven core technology enables rapid design, development, and transfer into commercial manufacturing, Consists of a metal substrate that is heated through an exothermic chemical reaction, The substrate can be coated with milligrams of drug compound, Consists of a reusable controller and a disposable dose cartridge. Alexza has completed feasibility testing of over 400 compounds, approximately half of which have demonstrated positive initial vaporization feasibility, resulting in high-purity aerosols when vaporized at an appropriate film thickness and temperature. Staccato OBT products are designed with patients in mind. The Staccato OBT products generate a PK profile generally observed by IV delivery (i.e., same Tmax and Cmax). AVE MARIA (v. Elizabeth Mulliner) T554-1 (A-2447) MAJ1108-07/? See more of Favij on Facebook. staccato. They fulfill a significant unmet medical need by providing new treatment options to patients and physicians. After the initial feasibility study, the path to IND will often depend on conducting IND-enabling inhalation toxicology studies and optimizing the delivery platform for a specific compound. The Staccato OBT system is suited for delivery of drug combinations (e.g., two different actives). Lv 5. The Staccato OBT system delivers pure (unformulated) drug, which reduces development time as formulation development is not required. Ma se "tutto attaccato" si scrive staccato, perchè "staccato" si scrive tutto attaccato?? The key to our proprietary technology is vaporization of drug without thermal degradation achieved by rapid heating of the drug film to generate consistent aerosol particles of 1–5 microns in size that are optimal for deep lung inhalation; it is not dependent on mechanics or preformed drug particles to create drug aerosols. agg. A staccato ellentéte a legato, mely hosszan kitartott, folytonos játékmódot jelent. Staccato is a Chennai based band, popularizing the genre Contemporary Classic, keen on giving an experiential listening to its audience. Knihy VypoÅ¥te své modlitby - Pohyb jako duchovní praxe-- autor: Roth Gabrielle Kapry bijem-- autor: Pilipiuk Andrzej ALEXZA PHARMACEUTICALS Rychlý překlad slova staccato do čeÅ¡tiny, výslovnost, tvary a příklady užití. Staccato je styl hudebního přednesu, kdy jsou jednotlivé tóny hrány s co nejvýraznějÅ¡ím oddělením. The Staccato OBT system comprises the rapid vaporization of an excipient-free drug to form aerosol particles optimal for systemic delivery through inhalation. Based on our experience with the screened compounds, an initial assessment can be made as to whether a particular drug will generate an aerosol with an acceptable purity profile. Generovaný, orientační výčet dalÅ¡ích tvarů tohoto slova. The interior of the upper part of the instrument is inscribed with Maria's initials, The Staccato OBT system matches delivery characteristics and product attributes to patient needs for rapid and effective treatment of acute and intermittent conditions. Rapid heating of a thin film of excipient-free drug creates a drug aerosol without thermal degradation. Log In. Learn more. Johnny Staccato is an American private detective series starring John Cassavetes which ran for 27 episodes on NBC from September 10, 1959 through March 24, 1960. Help me! Staccato na Zalando UK | Objevte velký výběr a využijte bezplatné dopravy a vrácení zboží zdarma | Objednejte Staccato na Zalando hned teď! The dose cartridge contains up to 25 doses coated onto individual metal substrates, Each metal substrate rapidly heats upon application of battery-supplied electric current and can be coated with micrograms of drug compound, Consists of a reusable controller and a disposable dose cartridge. In addition, particle size optimization is often performed in order to assure deep lung delivery. Translations in context of "staccato" in Italian-English from Reverso Context: si è staccato, staccato la testa, staccato la spina, staccato dal, quasi staccato. Some of our notable performances at prestigious venues are as follows: Double Edge is the celebration of two similar but distinct sounds that emanate from Chennai and celebrate all things global, In one evening, two bands delve into their Carnatic roots, then spin fresh, spirited melodies, The band members of Staccato explain what makes their original compositions & signature rejigs of established tracks, stand out, Chennai-based band Staccato played to thunderous applause over the weekend, The band stayed true to being all-round entertainers at the global concert series, Staccato and Indosoul have their own stylistic identities in contemporary presentations, Chennai-based Staccato is elated over being selected to perform at the Olympics in London, Finding an audience of different age groups enjoying a similar genre of music can sometimes be rare, For Enquiries - contactstaccato@gmail.com, The only band to have been chosen from India to perform at the 2012 London Olympics.